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. 2021 Dec 21;12:796590. doi: 10.3389/fphar.2021.796590

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Copyright © 2021 Li, Hou, Wang, Dai, Zhang, Tang, Dong, Yan, Wang, Li and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DG suppressed ileal FXR-FGF15 metabolic signaling to impact rate-limiting enzyme of hepatic bile acids (BAs) biosynthesis in high fat diet mice. (A) Relative mRNA expression of ileal FXR (n = 8). (B) Relative mRNA expression of liver BA synthase CYP7A1 (n = 8). (C) Relative protein expression levels of FXR and FGF15 in ileum (n = 6). (D) Immunofluorescence staining of ileal FGF15 (red, scale bar: 100 μm). Values were denoted as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. Abbreviations: DG, diammonium glycyrrhizinate. FXR, farnesoid X-activated receptor. FGF15, fibroblast growth factor 15.