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. 2021 Dec 21;12:796590. doi: 10.3389/fphar.2021.796590

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Copyright © 2021 Li, Hou, Wang, Dai, Zhang, Tang, Dong, Yan, Wang, Li and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DG changed gut microbiota composition and diminished BSH enriched microbes in high fat diet mice. (A) OTU Venn diagram between 5 groups. (B) Relative abundance of gut microbiota at phylum level. (C) Weighted Unifrac Anosim analysis between 5 groups. (D) Differential analysis in the cladogram by LEfSe. (E) PCA results of different bacterial taxa at the genus level. (F) Relative abundance for specific bacterial genera of each group. n = 8 each group. Abbreviations: DG, diammonium glycyrrhizinate. BSH, bile-salt hydrolase. OTU, operational taxonomic unit. LEfSe, linear discriminant analysis effect size. PCA, principal components analysis.