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. 2021 Dec 21;12:796590. doi: 10.3389/fphar.2021.796590

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Copyright © 2021 Li, Hou, Wang, Dai, Zhang, Tang, Dong, Yan, Wang, Li and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DG altered BA profiles and increased proportion of conjugated BAs in high fat diet mice. (A) Fecal levels of differential BAs. (B-C) Changes in differential BAs composition. (D) Spearman correlation analysis between differential BAs and conventional index including weight gain, eWAT, fasting glucose, fasting insulin, and ileum FXR. (E) Heat map of spearman correlation between BAs and gut microbiota at genus level identified with significant difference in fecal samples of each mice. + p < 0.05; *p < 0.01. Values were denoted as mean ± SEM (n = 5). *p < 0.05; **p < 0.01; ***p < 0.001. Abbreviations: DG, diammonium glycyrrhizinate. BAs, bile acids. eWAT, white adipose tissue of the epididymis. FXR, farnesoid X-activated receptor.