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. 2021 Dec 21;12:796590. doi: 10.3389/fphar.2021.796590

FIGURE 8.

FIGURE 8

Gut microbiota from DG treatment relieved intestinal barrier impairment. (A) Relative mRNA expression of colonic MUC2, occludin and ZO-1 of recipient mice in FMT experiment (n = 5). (B) Relative mRNA expression of colonic IL-1β, IL-6 and TNF-α of recipient mice in FMT experiment (n = 5). (C) Relative protein expression of colonic ZO-1 and claudin three of recipient mice in FMT experiment (n = 4). (D) Immunofluorescence staining for ZO-1 distribution in colon tissues (red, scale bar: 100 μm) of recipient mice in FMT experiment. Values were denoted as mean ± SEM. **p < 0.01. Abbreviations: DG, diammonium glycyrrhizinate. HFD, high fat diet. MUC2, mucin 2. ZO-1, zonula occludens 1. FMT, fecal microbiota transplantation. IL-1β, interleukin-1beta. IL-6, interleukin-6. TNF-α, tumor necrosis factor-α.