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. 2021 Dec 21;12:758049. doi: 10.3389/fphar.2021.758049

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Copyright © 2021 Zeng, Yi, Su, Ye, Sun, Zhou, Lu, Shi and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CR treatment significantly ameliorates cerebral ischemic injury. Representative images of TTC-stained brain slices obtained 24 h (A), or 7 days (B) after global cerebral ischemia surgery. (C) Body weight changes were monitored over a 7-day period. (D) The time on the rod in the rotarod test on day 3 (n = 6/group). ** p < 0.01, *** p < 0.001 vs. Sham; ## p < 0.01, ### p < 0.001 IS + CR vs. IS. (E) Representative images of HE staining of the cortex after 7 days of CR treatment. Normal cortical neurons revealed normal cells with rich cytoplasm and round and slightly stained nucleus with relatively large and clear nucleolus formation. Scale bar = 50 µm. (F) The phytochemicals identified by UHPLC/MS/MS in the brains of Sham and IS mice that were orally administered CR. (G) Four components detected only in the brains of CR treated IS mice.