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. 2020 Dec 8;20:100012. doi: 10.1074/mcp.RA120.002256

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© 2020 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig. 3 — N-glycan imaging of a representative stage 3 PDAC tumor tissue.A, H&E staining of T3NXMX PDAC tissue with annotations. B, overlay of 4 representative N-glycans corresponding to necrotic tissue (red, Hex6HexNAc5 m/z 2028.7136), adenocarcinoma (green, Hex6dHex1HexNAc6 m/z 2377.8509), tumor margin (white, Hex9dHex1HexNAc8 m/z 3270.1681) and adjacent non-tumor tissue (blue, Hex5dHex1HexNAc4 m/z 1809.6393). C, N-glycan structures localized to necrotic tissue (top to bottom) Hex7HexNAc6 m/z 2393.8458, Hex6HexNAc5 m/z 2028.7136, and Hex5HexNAc4 m/z 1663.5814. D, N-glycan structures localized to adenocarcinoma tumor (top to bottom) Hex7dHex1HexNAc7 m/z 2742.9831, Hex6dHex1HexNAc7 m/z 2580.9302, and Hex6dHex1HexNAc6 m/z 2377.8509. E, N-glycan structures localized to tumor margin (top to bottom) Hex9dHex1HexNAc8 m/z 3270.1681, Hex8dHex1HexNAc7 m/z 2905.0359, and Hex7dHex1HexNAc6 m/z 2539.9037. F, N-glycan structures localized to adjacent nontumor tissue (top to bottom) Hex6dHex1HexNAc5 m/z 2174.7715, Hex5dHex1HexNAc4NeuAc1 m/z 2100.7347, and Hex5dHex1HexNAc4 m/z 1809.6393. PDAC, pancreatic ductal adenocarcinoma.