Fig. 6.

TMA cores grouped by CA19-9 and sTRA expression.A, individual patient core pairs analyzed by SCiLS Lab were extracted from each of the 4 TMAs and grouped in one of four designations based on biomarker expression. Four representative sorted TMA heat maps for N-glycans m/z 2581.9339, m/z 2742.9831, m/z 3036.1023, and m/z 3328.2181 are shown. Average Log₂ fold change between patient-matched tumor and normal cores across the four groupings for (B) nonsialylated N-glycans and for (C) amidation–amidation–stabilized sialic acid containing N-glycans. Positive values represent enrichment in tumor tissues. CA19-9, carbohydrate antigen 19-9; sTRA, sialylated tumor-related antigen; TMAs, tissue microarrays.