Figure 6. Proposed ERCYS’ working model.
Cartoon showing our working model, in cancer cells, basal ER stress promotes reflux of some PDI and PDI‐L proteins including AGR2 to the cytosol. In the cytosol, AGR2 is able to bind and inhibit p53 function.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.