Table 6.
Top 20 identified global SARS-CoV-2 spike protein mutations
| Mutant amino acid position | Domain of S protein | Number of sequences detected | Percentage in total cases (%) | Latest month increased (2021/10/22-11/22) |
|---|---|---|---|---|
| D614G | S1 CTD | 4,389,691 | 96.47 | 5.0 |
| L452R | RBM | 2,370,119 | 52.09 | 9.6 |
| P681R | S1 CTD | 2,330,791 | 51.22 | 9.9 |
| T478K | RBM | 2,315,734 | 50.89 | 9.9 |
| T19R | S1 NTD | 2,311,542 | 50.80 | 9.9 |
| D950N | S2 | 2,230,596 | 49.02 | 10.1 |
| EFR156G | S1 NTD | 2,178,419 | 47.87 | 10.3 |
| G142D | S1 NTD | 1,443,479 | 31.72 | 13.7 |
| N501Y | RBM | 1,103,940 | 24.26 | 0.0 |
| P681H | S1 CTD | 1,038,019 | 22.81 | 0.0 |
| HV69- | S1 NTD | 980,548 | 21.55 | 0.0 |
| T716I | S2 | 978,901 | 21.51 | 0.0 |
| A570D | S1 CTD | 972,330 | 21.37 | 0.0 |
| S982A | S2 | 971,209 | 21.34 | 0.0 |
| T95I | S1 NTD | 970,839 | 21.33 | 0.0 |
| D1118H | S2 | 970,596 | 21.33 | 1.0 |
| Y144- | S1 NTD | 960,965 | 21.12 | 13.3 |
| A222V | S1 NTD | 395,936 | 8.70 | 6.5 |
| E484K | RBM | 192,337 | 4.23 | 0.0 |
| L18F | S1 NTD | 190,391 | 4.18 | 0.5 |
S1 S1 subdomain, NTD N-terminal domain, RBD receptor-binding domain, RBM receptor-binding motif, CTD C-terminal domain, S2 subdomain 2. The data for 4,450,473 sequences from the COVID-19 started to November 22, 2021 were collected from GISAID and COVID CG