Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 7;30(1):72–79. doi: 10.4062/biomolther.2021.149

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022, The Korean Society of Applied Pharmacology

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Fig. 5 — Effects of inhibitors of JAK2/STAT3 signaling in human skin cancer cells. (A) A375 and A431 cells were treated with the indicated concentrations of LCH, cryptotanshinone (CTS), and S3I-201 for 48 h. Western blot analysis to detect the levels of JAK2, p-JAK2, STAT3, and p-STAT3. β-Actin was used as the loading control. (B) The percentages of p-JAK2 and p-STAT3 expression is shown. The data represent mean percentages ± SD (n=3; ***p<0.001). (C) Viability of A375 and A431 skin cancer cell lines treated with the indicated concentrations of LCH, CTS, and S3I-201 for 48 h measured using the MTS reagent. The data represent mean percentages ± SD (n=3; ***p<0.001).