TABLE 1.
Characteristic | Patient 1 | Patient 2 |
---|---|---|
Age (y) | 35 | 70 |
Sex | Male | Male |
Height (cm) | 183 | 193 |
Body weight (kg) | 94 | 85 |
Oncologic diagnosis | Metastatic, well-differentiated, nonfunctional malignant paraganglioma (initial presentation as right glomus caroticum tumor) | Metastatic, functional NEN of pancreatic tail |
Metastases | Lymph node, pulmonary, hepatic, osseous | Lymph node, hepatic, pulmonary, osseous, peritoneal |
Proliferation rate (Ki-67) | 5% | 4% |
Initial diagnosis | September 2011 | September 1996 |
Genetic predisposition | c.301G > T (p.Gly101Trp) heterozygous CDKN2A | N/A |
Karnofsky Performance Score (at time of this study) | 90% | 80% |
Previous treatments* | Surgery (2011) | Surgery (1996/2017) |
Radiochemotherapy (2011) | Chemotherapy (everolimus; 2016) | |
Radionuclide therapy (2017) | Radionuclide therapy (2017) |
Detailed descriptions of previous treatments are provided in Supplemental Table 1.
N/A = not available.