Fig. 1.
Graphical representation of quantitative glycomics and glycoproteomic analyses. Glycomic evaluations, as discussed here, may take place at either the glycan or glycopeptide level and pursued through incorporation of stable isotopes, deposition of isotopic labels for MS1 level quantification, isobaric labeling for MS2 level quantitation, or label-free comparison. Both data-dependent and data-independent acquisition are effectively employed for glycome or glycopeptide detection with numerous software tools available to perform identification and quantitative analysis.