Table 2.
High DRiP factor peptides derived from ribosomal protein subunits
| Source protein | HLA peptides | DRiP factor IFN-γ 20 h | DRiP factor IFN-β 20 h | Involved in ribosome biogenesis and associated with ribosomopathiesa | Involved with viral infections |
|---|---|---|---|---|---|
| RPL10A | TLYEAVREV | 9.3 | 7.2 | (98) | |
| NMVAKVDEV | 14.1 | 10.5 | |||
| NENMVAKV | 25.0 | 21.7 | |||
| RPL15 | ILIDPFHKA | 6.7 | 28.0 | (107) | (97) |
| RPL24 | RTDGKVFQF | 13.2 | 12.1 | ||
| RPL26; RPL26L1 | DEVQVVRGHY | 17 | 19.7 | (108) | |
| DEVQVVRGH | 18.1 | 16.1 | |||
| RPL28 | AADGKGVVV | 36.8 | 34.7 | ||
| RPL31 | NEVVTREY | 28.4 | 22.7 | (109) | |
| RPL34 | FLIEEQKIVV | 10.8 | 15.4 | ||
| RPL35A | ALLKIEGVYA | 9.6 | 4.0 | ||
| RPL5 | KIYEGQVEV | 10.9 | 6.5 | ||
| RPL7 | MEDLIHEIY | 16.6 | 10.4 | (99) | |
| RPS15A | VLADALKSI | 7.5 | 13.4 | (110) | |
| RPS16; ZNF90 | YVDEASKKEI | 46.2 | 1.3 | ||
| RPS17 | ALDQEIIEV | 15.2 | 3.7 | (111, 112, 113, 114, 115) | |
| RPS23 | DEVLVAGF | 6.7 | 11.6 | (116) | (101) |
| VGDIPGVRF | 56.3 | 47.6 | |||
| RPS3 | YVDTAVRHV | 66.0 | 51.9 | (102) | |
| RPS3A | GLKGRVFEV | 8.0 | 11.9 | (117) | |
| LADLQNDEV | 9.2 | 21.3 | |||
| RPS4X | SIDKTGENF | 50.3 | 53.4 | (118) | |
| RPS5 | AETPDIKLF | 4.0 | 16.9 | ||
| VAETPDIKL | 162.4 | 47.2 | |||
| RPS7 | VEHKVETF | 25.3 | – | (111, 119, 120, 121) | (122) |
| RPS8 | RIIDVVYNA | 21.0 | 18.7 | (123) |
a
Information regarding the involvement of these proteins in ribosomopathies (105).