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PAKib inhibited the kinase activity of PAK4. In an in vitro kinase assay using myelin basic protein (MBP) as substrate, PAKib suppressed the kinase activity of PAK4 (immune-precipitated from PANC-1 cell) with an IC50 value about 500 nM (A, B), and of a recombinant PAK4 (C, D). pMBP: phosphorylated MBP; tMBP: total MBP; CT: control. The density of pMBP from 0 (PAKib, B) or CT (D) were taken as 1 or 100% respectively.
