Table 2.
PAKib down-regulated phosphorylated proteins involved in KEGG pathways
| Gene names | KEGG pathways |
|---|---|
| ZAK | MAPK signaling pathway;Tight junction |
| PML | Acute myeloid leukemia;Endocytosis;Pathways in cancer;Ubiquitin mediated proteolysis |
| HMGCR | Bile secretion;Terpenoid backbone biosynthesis |
| PSD3 | Endocytosis |
| LMNA | Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;Hypertrophic cardiomyopathy (HCM) |
| ITGB4 | Arrhythmogenic right ventricular cardiomyopathy (ARVC);Dilated cardiomyopathy;ECM-receptor interaction;Focal adhesion;Hypertrophic cardiomyopathy (HCM);Regulation of actin cytoskeleton |
| ARHGEF11 | ko05152;Vascular smooth muscle contraction |
| STK11 | Adipocytokine signaling pathway;mTOR signaling pathway |
| UBE3A | Ubiquitin mediated proteolysis |
| ACLY | Carbon fixation pathways in prokaryotes;Citrate cycle (TCA cycle) |
| NCOR2 | Notch signaling pathway |
| IRS1 | Adipocytokine signaling pathway;Aldosterone-regulated sodium reabsorption;Insulin signaling pathway;Neurotrophin signaling pathway;Type II diabetes mellitus |
| SMC4 | Cell cycle - yeast |
| ACSS2 | Carbon fixation pathways in prokaryotes;Glycolysis / Gluconeogenesis;Methane metabolism;Propanoate metabolism;Pyruvate metabolism |
| LLGL2;LLGL1 | Tight junction |
| ABLIM1 | Axon guidance |