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. 2022 Jan 3;23:1. doi: 10.1186/s12864-021-08243-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The reconstruction process of the lncRNA–miRNA–mRNA network. First, miRNA expression data were downloaded from two previous studies (GSE159507 and GSE159508). Second, differentially expressed mRNAs, lncRNAs, and miRNAs were screened. Third, target mRNAs of miRNAs were predicted using miRanda, and target lncRNAs of differentially expressed microRNAs were predicted using miRanda. Then, differentially expressed lncRNAs and mRNAs were merged with the target lncRNAs and mRNAs of differentially expressed miRNAs, respectively. The node degree of the selected lncRNA was more than 8. The coexpressed lncRNAs and mRNAs were selected (Pearson correlation coefficient > 0.90 and P < 0.001). Finally, the differentially expressed miRNAs, coexpressed lncRNAs and mRNAs were mapped into the interactions. lncRNA, long noncoding RNA; miRNA, microRNA; mRNA, messenger RNA