Table 2.
Association of SNPs and haplotypes of OXSR1 with the number of exacerbations during the 1st year of follow up in non-smoker subjects
| Locus | No. of exacerbations, Mean ± SE (N) | Codomiant | Dominant | Recessive | |||||
|---|---|---|---|---|---|---|---|---|---|
| CC | CR | RR | P* | Pcorr | P* | Pcorr | P* | Pcorr | |
| rs9839010 | 0.41 ± 0.03 (600) | 0.28 ± 0.03 (308) | 0.34 ± 0.11 (47) | 0.038 | 0.383 | 0.011 | 0.114 | 0.268 | 1.000 |
| rs61005484 | 0.38 ± 0.03 (845) | 0.25 ± 0.06 (108) | 0.5 ± 0.5 (2) | 0.445 | 1.000 | 0.218 | 1.000 | 0.881 | 1.000 |
| rs4955408 | 0.31 ± 0.04 (342) | 0.44 ± 0.04 (462) | 0.28 ± 0.05 (150) | 0.081 | 0.811 | 0.090 | 0.905 | 0.411 | 1.000 |
| rs1392283 | 0.39 ± 0.03 (758) | 0.27 ± 0.04 (183) | 0.15 ± 0.1 (13) | 0.045 | 0.453 | 0.013 | 0.128 | 0.597 | 1.000 |
| rs112221585 | 0.37 ± 0.03 (817) | 0.33 ± 0.07 (131) | 0.33 ± 0.33 (3) | 0.846 | 1.000 | 0.566 | 1.000 | 0.875 | 1.000 |
| rs74919163 | 0.31 ± 0.03 (481) | 0.46 ± 0.04 (389) | 0.21 ± 0.07 (66) | 0.041 | 0.413 | 0.031 | 0.307 | 0.532 | 1.000 |
| rs1384006 | 0.43 ± 0.04 (541) | 0.28 ± 0.03 (356) | 0.31 ± 0.09 (58) | 0.015 | 0.153 | 0.004 | 0.039 | 0.476 | 1.000 |
| rs156260 | 0.37 ± 0.03 (736) | 0.36 ± 0.06 (206) | 0 ± 0 (13) | 0.635 | 1.000 | 0.928 | 1.000 | 0.344 | 1.000 |
| rs9880223 | 0.38 ± 0.03 (845) | 0.25 ± 0.06 (108) | 0.5 ± 0.5 (2) | 0.445 | 1.000 | 0.218 | 1.000 | 0.881 | 1.000 |
| rs2298417 | 0.35 ± 0.03 (683) | 0.4 ± 0.05 (247) | 0.58 ± 0.15 (24) | 0.120 | 1.000 | 0.131 | 1.000 | 0.080 | 0.802 |
| rs2011 | 0.4 ± 0.03 (634) | 0.3 ± 0.04 (284) | 0.24 ± 0.09 (37) | 0.067 | 0.673 | 0.020 | 0.201 | 0.490 | 1.000 |
| Block1_ht1 | 0.34 ± 0.05 (216) | 0.42 ± 0.04 (506) | 0.28 ± 0.04 (233) | 0.120 | 0.360 | 0.077 | 0.231 | 0.646 | 1.000 |
| Block1_ht2 | 0.3 ± 0.06 (108) | 0.44 ± 0.04 (435) | 0.3 ± 0.03 (412) | 0.029 | 0.087 | 0.025 | 0.075 | 0.513 | 1.000 |
| Block2_ht2 | 0.47 ± 0.14 (34) | 0.37 ± 0.05 (309) | 0.36 ± 0.03 (612) | 0.768 | 1.000 | 0.814 | 1.000 | 0.469 | 1.000 |
The italic, underlined P values indicate statistical significance (P < 0.05)
CC common allele homozygote, CR heterozygote, RR minor allele homozygote, SE standard error of mean, Pcorr corrected P value for multiple comparisons
Pcorr corrected P values using the effective number of independent marker loci (MeffLi) calculated by SNPSpD for each SNP (MeffLi = 10.03501), and using the number of haplotypes (n = 3) for each haplotypes
*Adjusted for age, sex, serum total IgE level, predicted FEV1% at the first visit, and total ICS and systemic steroid dose in the 1st year of visit as covariates