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Associations between mtDNAcn and D-loop methylation levels. A In the total population, mtDNAcn is negatively correlated with D-loop methylation (r = − 5.154, P < 0.001). B In the male population, mtDNAcn is negatively correlated with D-loop methylation (r = − 4.184, P = 0.004). C In the female population, mtDNAcn is negatively correlated with D-loop methylation (r = − 7.726, P < 0.001). All tests were performed by Pearson correlation analysis
