Table 4.

Associations between mtDNAcn and D-loop methylation levels

D-loop methylation	mtDNAcn
	Crude β (95% CI)	P	Adjusted β (95% CI)	Pa
Total
Tertile 1	Reference		Reference
Tertile 2	− 12.23 (− 22.71,− 1.75)	0.022	− 14.39 (− 24.35,− 4.42)	0.005
Tertile 3	− 8.79 (− 11.99,− 5.59)	< 0.001	− 9.11(− 12.33,− 5.88)	< 0.001
P for Trend		< 0.001		< 0.001
Continuous	− 5.15 (− 7.24,− 3.07)	< 0.001	− 5.74 (− 7.80,− 3.69)	< 0.001
Male
Tertile 1
Tertile 2	− 15.86 (− 24.66,− 4.07)	< 0.001	− 16.61(− 25.28,− 7.95)	< 0.001
Tertile 3	− 10.01(− 15.62,− 4.41)	0.001	− 10.65 (− 16.10,− 5.19)	< 0.001
P for Trend		< 0.001		< 0.001
Continuous	− 4.18 (− 6.95,− 1.42)	0.003	− 4.32 (− 7.04,− 1.60)	0.019
Female
Tertile 1
Tertile 2	− 17.03 (− 29.46,− 4.60)	0.007	− 19.55 (− 32.96,− 6.14)	0.004
Tertile 3	− 9.99 (− 13.70,− 6.28)	< 0.001	− 10.44 (− 14.08,− 6.81)	< 0.001
P for Trend		< 0.001		< 0.001
Continuous	− 7.73 (− 10.77,− 4.68)	< 0.001	− 7.65 (− 10.56,− 4.74)	< 0.001

^aAdjust for gender, age, hypertension, diabetes mellitus, dyslipidemia