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. 2022 Jan 4;24:1. doi: 10.1186/s13058-021-01497-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — circCCDC85A inhibits proliferation, migration and invasion of breast cancer cells. A The expression of circCCDC85A in three breast cancer cell lines was detected by qRT-PCR. B The expression of circCCDC85A and linear CCDC85A mRNA in MDA-MB-231 cells after transfection with circCCDC85A or pLC5-ciR empty vector were detected by qRT-PCR. C, D The proliferation viability and colony formation ability of MDA-MB-231 cells transfected with circCCDC85A or pLC5-ciR empty vector were evaluated by CCK-8 assay and colony formation assay. E–G The migration and invasion abilities of MDA-MB-231 cells transfected with circCCDC85A or pLC5-ciR empty vector were evaluated by wound healing assay, transwell migration and invasion assay. H The knocking down efficiency of circCCDC85A siRNA in MCF-7 cells was examined by qRT-PCR. I, J The proliferation viability and colony formation ability of MCF-7 cells transfected with circCCDC85A siRNA or NC siRNA were evaluated by CCK-8 assay and colony formation assay. K–M The migration and invasion abilities of MCF-7 cells transfected with circCCDC85A siRNA or NC siRNA were evaluated by wound healing assay, transwell migration and invasion assay. *P < 0.05, **P < 0.01, ***P < 0.001