Fig. 3.

Inducing infection-refractory states in vector microbiome. a Chains of infection of vector-borne diseases such as those transmitted by ticks involve matching (black lines) among competent vectors (red circle), infectious pathogens (blue circle) and an infection-compatible microbiome (yellow circle). b Mismatches between at least two of the components can result in an impaired ability of the vector to transmit pathogens. c Microbiome manipulation using anti-microbiota vaccines that elicit microbiota specific antibodies can be used to induce infection-refractory states (gray lines) in vector microbiome in which microbiome manipulation results in transmission blocking despite matching between pathogen and vector genetics (black line). Created with BioRender.com