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. 2022 Jan 3;23:8. doi: 10.1186/s12891-021-04947-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — HDAC4 and m-HDAC4 attenuate articular cartilage damage. a The Ad-m-HDAC4 treated rats had stronger Safranin O staining and less-damaged cartilage surface than the Ad-HDAC4 treated rats. The most severe Safranin O staining lost and cartilage surface damage were detected in rats that underwent ACLT operation and treated with Ad-GFP. Top panel scale bars: 100 μm; bottom panel scale bars: 50 μm. b OARSI scores were lower in in the Ad-m-HDAC4 treated rats than in the Ad-HDAC4 treated rats. The OARSI scores was highest in the ACLT rats and treated with Ad-GFP and sham-operated rats had the lowest scores. * indicates P < 0.05.