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Summary of the ApoE- and sex-modulated metabolic alterations in fatty acid-related pathways during early cognitive decline. Abbreviations: CD, cognitive decline; CTL, control; ε4+, carrier of the ε4 allele of the apolipoprotein E gene; ε4-, non-carrier of the ε4 allele of the apolipoprotein E gene; F, females; M, males; SFA, saturated fatty acids; PUFA; polyunsaturated fatty acids
