Fig. 5.

IacsRNA in vivo inhibited patient-derived tumor xenograft colon carcinoma in NOD/SCID mice. A Schematic diagram of PDX model construction. B Detection of tumor mutations by exon sequencing. WT stands for wild type. C Representative tumor sections after the indicated treatment staining by immunohistochemistry (scale bar: 100 μm). D Tumor growth curves in PDX mouse model mice with the indicated treatments (n = 5). E Tumor growth inhibition (TGI) with the indicated treatment at day 13. F, G Representative photographs (F) and weight of tumor (G) after the indicated treatments. H, I Ki67 (H) and TUNEL (I) staining in tumor sections from mice with the indicated treatments (scale bar: 100 μm). The data were presented as mean ± s.d. Statistical analysis was performed using t test, *, p < 0.05; **, p < 0.01; ***, p < 0.001