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. 2022 Jan 3;22:1. doi: 10.1186/s12935-021-02402-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Overexpression of CCNE1 in SCUBE3 knockdown Bel7404 cells regulates proliferation and apoptosis. A MTT proliferation assay. B caspase 3/7 activity assay. C Detection of apoptosis in cells with both SCUBE3 knockdown and CCNE1 overexpression and control cells by the Annexin V-APC/PI double staining assay and, D cell cycle analysis of cells with both SCUBE3 knockdown and CCNE1 overexpression and control cells. E SCUBE3 knockdown cells were treated with overexpression lentivirus of CCNE1 for 72 h, Cell lysates were analyzed by immunoblotting using the indicated antibodies (*p < 0.01, **p < 0.01,***p < 0.001)