Table 3.

Comparisons of discriminating abilities of tested biomarkers presented as areas under the curve (95% CI)

Tested biomarker	AUC (95% CI)	p value	Cut-off value	Sensitivity, (%)	Specificity, (%)
Presepsin
Sepsis vs. non-infectious organ failure	0.877 (0.841–0.906)	< 0.001	582 (pg/mL)	70.1	89.4
Septic shock vs. sepsis	0.618 (0.558–0.675)	< 0.001	1285 (pg/mL)	50.4	76.6
Procalcitonin
Sepsis vs. non-infectious organ failure	0.908 (0.877–0.934)	< 0.001	0.51 (ng/mL)	75.5	93.0
Septic shock vs. sepsis	0.678 (0.619–0.732)	< 0.001	2.81 (ng/mL)	59.1	70.9
CRP
Sepsis vs. non-infectious organ failure	0.858 (0.821–0.890)	< 0.001	3.53 (mg/L)	77.0	85.2
Septic shock vs. sepsis	0.559 (0.498–0.618)	0.088	6.62 (mg/L)	65.7	46.8

AUC area under the curve, CRP C-reactive protein