Table 2.
Univariate and multivariate logistic regression analysis in estimation set
| Characteristics | All patients (n = 146) |
High-dose (n = 49) |
Standard-dose (n = 97) |
P value | |
|---|---|---|---|---|---|
| Univariate | Multivariate | ||||
| Male, n (%) | 96 (65.8) | 31 (63.3) | 65 (67.0) | 0.653 | |
| Age [years]a | 60.7 ± 15.0 | 52.0 ± 15.2 | 65.0 ± 12.9 | < 0.001 | 0.020 |
| Body weight [kg]a | 58.3 ± 12.9 | 63.1 ± 13.7 | 55.8 ± 11.9 | 0.002 | – |
| BMI [kg/m2]a | 21.9 ± 3.9 | 23.1 ± 4.3 | 21.3 ± 3.5 | 0.011 | – |
| SCr [mg/dL]a | 0.69 ± 0.23 | 0.62 ± 0.19 | 0.73 ± 0.24 | 0.003 | – |
| eCCr [mL/min]a | 95.9 ± 43.8 | 123.0 ± 40.4 | 82.2 ± 38.9 | < 0.001 | 0.001 |
| Initial VCM dose, nb | < 0.001d | ||||
| > 2 g/day | 11 (10/1/0) | 11 (10/1/0) | 0 (0/0/0) | ||
| =2 g/day | 108 (0/107/1) | 34 (0/34/0) | 74 (0/73/1) | ||
| < 2 g/day | 27 (1/19/7) | 4 (1/2/1) | 23 (0/17/6) | ||
| Day until first TDM [days]c | 4 (2–7) | 3 (2–7) | 4 (3–6) | 0.213e | |
| First Ctrough [μg/mL]a | |||||
| All patients | 13.0 ± 6.0 | 8.2 ± 3.8 | 15.5 ± 5.5 | < 0.001f | |
| > 2 g/day | 13.3 ± 3.5 | 13.3 ± 3.5 | – | – | |
| =2 g/day | 13.3 ± 6.1 | 6.8 ± 2.1 | 16.3 ± 4.9 | < 0.001f | |
| < 2 g/day | 11.8 ± 6.7 | 5.8 ± 3.5 | 12.8 ± 6.5 | 0.047f | |
| BE conducted, n (%) | 59 (40.4) | 33 (67.3) | 26 (26.8) | < 0.001d | |
aData are shown as mean ± standard deviation (SD)
bNumbers in parentheses indicate the number of patients with dosing intervals of 8 h, 12 h, and others from the left, respectively
cData are shown as median (range)
dχ2-test
eMann–Whitney U-test
fUnpaired student’s t-test
BMI body mass index, SCr serum creatinine, eCCr estimated creatinine clearance, Ctrough trough concentration of VCM, BE Bayesian estimation