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. Author manuscript; available in PMC: 2022 Jan 4.
Published in final edited form as: Am J Med Genet A. 2021 Jun 4;185(9):2719–2738. doi: 10.1002/ajmg.a.62362

FIGURE 2.

FIGURE 2

Clinical photographs and brain MR images for three individuals with CCND2-associated microcephaly. (a–c) T2-weighted brain MR images of patient LR19–002 at age 6 months. (a) Midsagittal image showing a mildly thin corpus callosum, with a relatively preserved cerebellar vermis; (b) axial image showing an overall simplified gyral pattern with foreshortened frontal lobes, normal ventricles and (c) coronal image showing also an overall simplified gyral pattern. (d–f) MRI of patient LR20–198a1 at age 4 years showing a mildly foreshortened frontal lobe and subtle simplified gyrification with no cortical malformations and no other major anomalies. (g and h) frontal and lateral pictures of individual LR20–198a1. (i–k) MRI of patient LR20–198a2 at age 2 years 5 months showing a normal appearance with no cortical malformations and no other major anomalies. (l and m) frontal and lateral pictures of patient LR10–198a2