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. 2022 Jan 4;13(1):e03144-21. doi: 10.1128/mBio.03144-21

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Copyright © 2022 Vadovics et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 2 — Effects of live Candida on HO-1-N-1 and HSC-2 oral squamous cell carcinoma cells in vitro. (A) Pictures from time-lapse videos of cellular migration of HSC-2 cells, with arrows pointing to detached cancer cells. The left picture shows the control cells, and the right shows the live C. albicans-treated cells. The graph shows the number of detached cells (n = 3). (B) Normalized total secreted matrix metalloproteinase activity of OSCC cells in the presence of live C. albicans and C. parapsilosis as obtained by a total MMP activity kit (n = 3). (C) Normalized amounts of metabolites of OSCC cells in the presence of live C. albicans and live C. parapsilosis as measured by HPLC-HRMS (n = 3). ASP, aspartic acid; GA-3P, glyceraldehyde-3P; MET, methionine; PRO, proline; SUC, succinic acid; FUM, fumaric acid; G/F-6P, glucose/fructose-6p; GLUT, glutamic acid; KET, α-ketoglutaric acid. Control, tumor cells without any treatment. Unpaired t test; *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001.