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. 2022 Jan 4;13(1):e03144-21. doi: 10.1128/mBio.03144-21

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Copyright © 2022 Vadovics et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 3 — In vitro transcriptomic analysis. Candida albicans activates genes and signaling pathways involved in the OSCC metastatic processes. (A) Number of up- or downregulated genes of HSC-2 and HO-1-N-1 cells after different fungal treatments (n = 3). C.a., C. albicans; C.p., C. parapsilosis (B) Venn diagram of up- or downregulated genes in HSC-2 cells in the presence of live C. albicans and OSCC invasion marker genes found in the literature. sig., significantly. (C) Venn diagram of up- or downregulated genes in the HSC-2 cell line in the presence of live C. albicans and EMT marker genes in HNSCC according to a single-cell sequencing study. (D) Venn diagram of up- or downregulated genes in HO-1-N-1 cells incubated with live C. albicans and OSCC invasion marker genes found in the literature. (E) Venn diagram of up- or downregulated genes in the HO-1-N-1 cell line in the presence of live C. albicans and EMT marker genes in HNSCC according to a single-cell sequencing study. (F) Signaling pathways that are key regulators of the OSCC invasion processes that were significantly activated in HSC-2 cells in the presence of live C. albicans. (G) Graph showing log₂ fold change of C. albicans-induced genes in HSC-2 cells involved in OSCC invasion according to the literature and of single-cell sequencing (scSeq) results from 18 patients with HNSCC. Red columns represent OSCC marker genes according to the literature and scSEQ data. (H) Graph showing log₂ fold change of C. albicans-induced genes in HO-1-N-1 cells involved in OSCC invasion according to the literature and scSEQ data. Red columns represent OSCC marker genes according to the literature and scSEQ data. (I) Causal analyses of the genes for which expression changed in HSC-2 cells after live Candida albicans treatment.