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. 2022 Jan 4;13(1):e03144-21. doi: 10.1128/mBio.03144-21

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Copyright © 2022 Vadovics et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 6 — Transcriptomic analysis of in vivo tumor samples followed by oral candidiasis. (A) Schematic figure of mRNA sequencing of OSCC xenograft and OC-OSCC xenograft tumor samples. The cartoon was produced by BioRender. (B) Venn diagram of up- or downregulated genes in HSC-2 cells in the presence of live C. albicans and OSCC invasion marker genes described in the literature. (C) Venn diagram of up- or downregulated genes in HSC-2 cell line in the presence of live C. albicans and EMT marker genes in HNSCC according to a single-cell sequencing study. (D) Graph showing log₂ fold change of C. albicans-induced genes in HSC-2 cells involved in OSCC invasion according to the literature and single-cell sequencing data. Red columns represent OSCC marker genes according to both the literature and single-cell sequencing (scSeq) results from 18 patients with HNSCC. (E) Tumor invasion genes showing upregulated expression both in vitro and in vivo. For transcriptomic analysis, n = 4. Created by BioRender.