FIG 6.

BL/6 and DBA mice differ in resistance to infection. (A) Fungal burden at day 4 p.i. Data are representative of results from two independent experiments (n = 4 to 6 mice/group). Zero values were set to the detection limit (50 colonies). (B) Fungal burdens in vaccinated and unvaccinated DBA and BL/6 mice at day 14 p.i. (n = 8 to 16 mice/group). Zero values were set to the detection limit (20 colonies). (C) Kaplan-Meier survival curve (n = 19 to 22 mice/group). Overall, the curves are statistically different (P < 0.0001). Vaccinated BL/6 mice survive significantly better than vaccinated DBA mice (P = 0.0151). Differences were determined by a Mantel-Cox rank test. All mice in these experiments received an inoculum of 2 × 10⁴ yeast cells.