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. 2001 Aug;21(16):5321–5331. doi: 10.1128/MCB.21.16.5321-5331.2001

FIG. 6.

FIG. 6

MPTP treatment of wild-type, heterozygous, and homozygous KA1 mice. (A) TH-immunopositive cells in sections from the substantia nigra pars compacta of saline-treated and MPTP-treated wild-type, heterozygous, and homozygous KA1 mice. (B) Number of TH-immunopositive cells in the substantia nigra pars compacta of saline-treated and MPTP-treated wild-type, heterozygous, and homozygous KA1 mice. TH-immunopositive cells were counted from 30 serial sections from 4 wild-type, 3 heterozygous, and 3 homozygous MPTP-treated and 4 saline-treated (2 homozygous and 2 wild-type) mice. The cell loss was significantly increased in MPTP-treated heterozygous and homozygous KA1 mice compared to the MPTP-treated wild-type littermates. The difference between the three groups was compared by the Student t test and showed a significant difference in the number of TH-positive cells between wild-type and heterozygous MPTP-treated mice (P < 0.01) and between wild-type and homozygous MPTP-treated mice (P = 0.001).