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. Author manuscript; available in PMC: 2022 Jan 4.
Published in final edited form as: Environ Int. 2020 Feb 7;137:105506. doi: 10.1016/j.envint.2020.105506

Figure 2.

Figure 2.

DEE exposure alters gene expression in a dose-dependent manner. a. The first principal component (PC1) of the DEE signature genes differs between samples from diesel exposed (n=41) and unexposed (n=38) individuals. b. PC1 of the DEE signature increases with increasing elemental carbon (EC) exposure (Cochrane-Armitage trend test p < 0.0001). The DEE-exposed individuals were divided based on tertiles of EC exposure levels (with the ranges given below each box) as described previously (Lan et al. (2015). The 38 non-DEE exposed individuals were assigned an EC exposure level of 11.1μg/m3 based on the mean of values measured at the control factories (Lan et al. 2015). Pair-wise comparisons were made using Student’s t-test. **** p < 0.0001. For each boxplot, the edges of the box are the 25th and 75th percentile of the data and the whiskers are the minimum and maximum values that do not exceed 1.5X the inter-quartile range.