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. Author manuscript; available in PMC: 2022 Jan 4.
Published in final edited form as: Environ Int. 2020 Feb 7;137:105506. doi: 10.1016/j.envint.2020.105506

Figure 3.

Figure 3.

Relationship between DEE and smoking-related gene expression. All of the genes measured on the microarray were ranked according to their degree of smoking-associated gene expression from most decreased (blue) to most increased (red). a. The position of the genes with increased expression in DEE-exposed individuals (n = 41) within the smoking-ranked list is indicated by the vertical lines, with the height of the line proportional to the GSEA running-enrichment score. The genes with increased expression in DEE-exposed individuals are significantly enriched among the genes most increased in current smokers (GSEA q < 0.001). The lines colored in purple represent the leading-edge gene set which comprised the most enriched genes. b. As in (a) but showing the position of the genes with decreased expression in DEE-exposed individuals (n = 41) within the smoking-ranked list. Significant enrichment of the genes with decreased expression in DEE-exposed individuals was not detected among the genes with smoking-associated expression levels (GSEA q = 0.43).