. 2021 Dec 31;14:1731–1751. doi: 10.2147/PGPM.S340813

Table 2.

Basic Information and Allele Frequencies About KCNQ1 Candidate SNPs in This Study

SNP	Chr	Position	Gene(s)	Role	Alleles	Frequency (MAF)		Call Rate (%)	p-HWE	OR (95% CI)	p value
SNP	Chr	Position	Gene(s)	Role	A/B	Cases	Controls	Call Rate (%)	p-HWE	OR (95% CI)	p value
rs117601636	11	2,620,807	KCNQ1	ncRNA exonic	A/G	0.085	0.093	100.00%	0.79	0.90 (0.67–1.23)	0.520
rs231362	11	2,670,241	KCNQ1	ncRNA exonic	C/T	0.135	0.126	100.00%	0.685	1.08 (0.84–1.40)	0.546
rs231356	11	2,684,113	KCNQ1	ncRNA exonic	A/T	0.216	0.224	99.90%	0.307	0.96 (0.78–1.18)	0.682
rs8181588	11	2,810,311	KCNQ1	Intronic	C/T	0.349	0.39	99.80%	0.851	0.84 (0.70–1.01)	0.061
rs163177	11	2,817,183	KCNQ1	Intronic	C/T	0.51	0.463	99.70%	0.788	1.21 (1.01–1.44)	0.036 *
rs163184	11	2,825,839	KCNQ1	Intronic	G/T	0.493	0.453	99.50%	0.527	1.18 (0.99–1.40)	0.071
rs2283228	11	2,828,300	KCNQ1	Intronic	A/C	0.311	0.368	99.60%	0.632	0.78 (0.65–0.93)	0.007 *
rs2237895	11	2,835,964	KCNQ1	Intronic	A/C	0.381	0.338	99.60%	0.319	1.20 (1.00–1.44)	0.046 *

Notes: p-HWE > 0.05 indicates that the genotypes were in Hardy-Weinberg Equilibrium; p values were calculated with Pearson’s χ 2 tests; *p values ≤ 0.05 indicates statistical significance. Data in bold are statistically significant (p < 0.05).

Abbreviations: SNP, single nucleotide polymorphism; Alleles A/B, Minor/Major alleles; MAF, minor allele frequency; OR, odds ratio; CI, confidence interval; HWE, Hardy–Weinberg equilibrium; Chr, chromosome; KCNQ1, Potassium Voltage-Gated Channel Subfamily Q Member 1.