Table 3.
Relationship Between KCNQ1 Gene Polymorphisms and Risk of T2DM Under Multiple Models of Inheritance
| SNP | Model | Genotype | Control | Case | Without Adjustment | With Adjustment | ||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | |||||
| rs163177 | Codominant | T/T | 143 (28.4%) | 106 (20.9%) | 1.00 | 1.00 | ||
| T/C | 254 (50.5%) | 285 (56.2%) | 1.51 (1.12–2.05) | 0.007 * | 1.52 (1.12–2.05) | 0.007 * | ||
| C/C | 106 (21.1%) | 116 (22.9%) | 1.48 (1.03–2.12) | 0.036 * | 1.48 (1.03–2.13) | 0.035 * | ||
| Dominant | T/T | 143 (28.4%) | 106 (20.9%) | 1.00 | 0.006 * | 1.00 | 0.006 * | |
| C/C-T/C | 360 (71.6%) | 401 (79.1%) | 1.5 (1.13–2.01) | 1.51 (1.13–2.01) | ||||
| Recessive | T/C-T/T | 397 (78.9%) | 391 (77.1%) | 1.00 | 0.488 | 1.00 | 0.488 | |
| C/C | 106 (21.1%) | 116 (22.9%) | 1.11 (0.82–1.5) | 1.11 (0.82–1.50) | ||||
| Log-additive | – | – | – | 1.22 (1.02–1.47) | 0.030 * | 1.22 (1.02–1.47) | 0.030 * | |
| rs163184 | Co-dominant | T/T | 153 (30.7%) | 128 (25.1%) | 1.00 | 1.00 | ||
| G/T | 240 (48.1%) | 260 (51.1%) | 1.3 (0.97–1.74) | 0.084 | 1.3 (0.97–1.74) | 0.082 | ||
| G/G | 106 (21.2%) | 121 (23.8%) | 1.36 (0.96–1.94) | 0.083 | 1.37 (0.96–1.95) | 0.079 | ||
| Dominant | T/T | 153 (30.7%) | 128 (25.1%) | 1.00 | 0.051 | 1.00 | 0.049 * | |
| T/G-G/G | 346 (69.3%) | 381 (74.9%0 | 1.32 (1.00–1.74) | 1.32 (1.00–1.74) | ||||
| Recessive | T/T-T/G | 393 (78.8%) | 388 (76.2%) | 1.00 | 0.337 | 1.00 | 0.329 | |
| G/G | 106 (21.2%) | 121 (23.8%) | 1.16 (0.86–1.56) | 1.16 (0.86–1.56) | ||||
| Log-additive | – | – | – | 1.18 (0.99–1.4) | 0.072 | 1.18 (0.99–1.40) | 0.068 | |
| rs2283228 | Co-dominant | C/C | 197 (39.4%) | 239 (47.0%) | 1.00 | 1.00 | ||
| A/C | 238 (47.6%) | 223 (43.8%) | 0.77 (0.59–1.00) | 0.054 | 0.77 (0.59–1.01) | 0.055 | ||
| A/A | 65 (13.0%) | 47 (9.2%) | 0.60 (0.39–0.91) | 0.016 * | 0.60 (0.39–0.91) | 0.016 * | ||
| Dominant | C/C | 197 (39.4%) | 239 (47.0%) | 1.00 | 0.016 * | 1.00 | 0.016 * | |
| A/C-A/A | 303 (60.6%) | 270 (53.0%) | 0.73 (0.57–0.94) | 0.74 (0.57–0.94) | ||||
| Recessive | C/C-A/C | 435 (87.0%) | 462 (90.8%) | 1.00 | 0.058 | 1.00 | 0.058 | |
| A/A | 65 (13.0%) | 47 (9.2%) | 0.68 (0.46–1.01) | 0.68 (0.46–1.01) | ||||
| Log-additive | – | – | – | 0.77 (0.64–0.93) | 0.007 * | 0.77 (0.64–0.93) | 0.007 * | |
| rs2237895 | Co-dominant | C/C | 214 (42.7%) | 193 (38.0%) | 1.00 | 1.00 | ||
| A/C | 235 (46.9% | 243 (47.8%) | 1.15 (0.88–1.49) | 0.311 | 1.15 (0.88–1.50) | 0.309 | ||
| A/A | 52 (10.2%) | 72 (34.6%) | 1.54 (1.02–2.31) | 0.039 * | 1.53 (1.02–2.30) | 0.039 * | ||
| Dominant | C/C | 214 (42.7%) | 193 (38.0%) | 1.00 | 0.127 | 1.00 | 0.126 | |
| A/C-A/A | 287 (57.3%) | 315 (62.0%) | 1.22 (0.95–1.57) | 1.22 (0.95–1.57) | ||||
| Recessive | C/C-A/C | 449 (89.8%) | 436 (65.4%) | 1.00 | 0.067 | 1.00 | 0.068 | |
| A/A | 52 (10.2%) | 72 (34.6%) | 1.43 (0.97–2.09) | 1.42 (0.97–2.08) | ||||
| Log-additive | – | – | – | 1.21 (1.01–1.46) | 0.044 * | 1.21 (1.01–1.46) | 0.044 * | |
Notes: p values were calculated with Pearson’s χ 2 tests; *p value < 0.05 indicates statistical significance (p < 0.05) are in bold.
Abbreviations: ORs, odds ratios; 95% CI, 95% confidence interval; KCNQ1, Potassium Voltage-Gated Channel Subfamily Q Member 1; T2DM, Type 2 diabetes mellitus.