Table 5.
Relationship of KCNQ1 Gene Polymorphisms and Risk of T2DM Stratified by Smoking and Drinking (Adjusted by Sex, Age)
| SNP | Model | Genotype | Smokers | Nondrinkers | Drinkers | Without Drinking History | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | |||
| rs231362 | Co-dominant | T/T | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| T/C | 0.73 (0.33–1.57) | 0.416 | 1.76 (1.05–2.98) | 0.034 * | 0.52 (0.04–6.03) | 0.599 | 2.01 (1.20–3.35) | 0.008 * | ||
| C/C | 0.89 (0.11–7.33) | 0.912 | 3.20 (0.35–29.56) | 0.305 | 0.31 (0.12–0.83) | 0.020 * | 3.63 (0.40–32.74) | 0.251 | ||
| Dominant | T/T | 1.00 | 0.427 | 1.00 | 0.023 * | 1.00 | 0.019 * | 1.00 | 0.005 * | |
| C/C-T/C | 0.74 (0.35–1.56) | 1.81 (1.08–3.04) | 0.33 (0.13–0.83) | 2.06 (1.25–3.42) | ||||||
| Recessive | T/C-T/T | 1.00 | 0.969 | 1.00 | 0.367 | 1.00 | 0.734 | 1 | 0.314 | |
| C/C | 0.96 (0.12–7.87) | 2.79 (0.30–25.93) | 0.65 (0.06–7.57) | 3.11 (0.34–28.20) | ||||||
| Log-additive | — | 0.79 (0.41–1.52) | 0.481 | 1.77 (1.09–2.87) | 0.021 * | 0.40 (0.18–0.93) | 0.033 * | 1.99 (1.24–3.20) | 0.005 * | |
| Allele | T | 1.00 | 0.719 | 1.00 | 0.081 | 1.00 | 0.084 | 1.00 | 0.032 * | |
| C | 1.10 (0.65–1.85) | 1.42 (0.96–2.11) | 0.55 (0.28–1.09) | 1.53 (1.04–2.25) | ||||||
| rs231356 | Co-dominant | T/T | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| T/A | 0.91 (0.45–1.86) | 0.795 | 1.05 (0.67–1.63) | 0.849 | 0.39 (0.17–0.89) | 0.024 * | 1.27 (0.82–1.97) | 0.279 | ||
| A/A | 0.92 (0.21–3.99) | 0.913 | 2.35 (0.72–7.63) | 0.157 | 0.40 (0.07–2.27) | 0.301 | 2.79 (0.87–8.93) | 0.084 | ||
| Dominant | T/T | 1.00 | 0.789 | 1.00 | 0.572 | 1.00 | 0.018 * | 1.00 | 0.136 | |
| A/A-T/A | 0.91 (0.46–1.8) | 1.13 (0.73–1.75) | 0.39 (0.18–0.85) | 1.38 (0.90–2.11) | ||||||
| Recessive | T/A-T/T | 1.00 | 0.950 | 1.00 | 0.161 | 1.00 | 0.503 | 1.00 | 0.110 | |
| A/A | 0.95 (0.23–4.04) | 2.31 (0.72–7.43) | 0.56 (0.10–3.08) | 2.56 (0.81–8.12) | ||||||
| Log-additive | — | 0.93 (0.54–1.63) | 0.809 | 1.21 (0.83–1.74) | 0.324 | 0.48 (0.25–0.93) | 0.030 * | 1.41 (0.98–2.02) | 0.066 | |
| Allele | T | 1.00 | 0.588 | 1.00 | 0.753 | 1.00 | 0.068 | 1.00 | 0.297 | |
| A | 1.12 (0.74–1.72) | 1.05 (0.76–1.46) | 0.61 (0.36–1.04) | 1.19 (0.86–1.63) | ||||||
| rs2283228 | Co-dominant | C/C | 1 | 1.00 | 1.00 | 1.00 | ||||
| A/C | 0.60 (0.3–1.23) | 0.162 | 0.83 (0.54–1.30) | 0.418 | 0.65 (0.31–1.36) | 0.25 | 0.79 (0.51–1.22) | 0.289 | ||
| A/A | 1.03 (0.31–3.4) | 0.963 | 0.58 (0.27–1.22) | 0.150 | 0.44 (0.08–2.51) | 0.359 | 0.72 (0.36–1.42) | 0.340 | ||
| Dominant | C/C | 1.00 | 0.233 | 1.00 | 0.244 | 1.00 | 0.201 | 1.00 | 0.224 | |
| A/C-A/A | 0.66 (0.33–1.31) | 0.78 (0.51–1.18) | 0.62 (0.30–1.29) | 0.78 (0.51–1.17) | ||||||
| Recessive | C/C-A/C | 1.00 | 0.602 | 1.00 | 0.204 | 1.00 | 0.494 | 1.00 | 0.505 | |
| A/A | 1.35 (0.44–4.16) | 0.63 (0.31–1.29) | 0.55 (0.10–3.01) | 0.80 (0.42–1.54) | ||||||
| Log-additive | — | 0.84 (0.50–1.40) | 0.506 | 0.79 (0.57–1.09) | 0.145 | 0.65 (0.35–1.22) | 0.182 | 0.83 (0.61–1.12) | 0.223 | |
| Allele | C | 1.00 | 0.868 | 1.00 | 0.043 * | 1.00 | 0.260 | 1.00 | 0.157 | |
| A | 0.97 (0.67–1.40) | 0.74 (0.55–0.99) | 0.77 (0.48–1.22) | 0.82 (0.61–1.08) | ||||||
Notes: p values were calculated by unconditional logistic regression analysis with adjustments for age; *p value < 0.05 indicates statistical significance (p < 0.05) are in bold.
Abbreviations: ORs, odds ratios; 95% CI, 95% confidence interval; KCNQ1, Potassium Voltage-Gated Channel Subfamily Q Member 1; T2DM, type 2 diabetes mellitus.