Table 7.
The Relationship Between KCNQ1 Genotype and Clinical Indicators of T2DM
| SNP | Genotype | Total Cholesterol | Triglycerides | LDL | HDL | ALBP | INS | UCRP | TJCTNT |
|---|---|---|---|---|---|---|---|---|---|
| rs117601636 | AA | 4.57±1.34 | 2.6±2.37 | 2.65±1.05 | 1.67±8.42 | 41.24±132.36 | 19.29±19.75 | 0.58±1.37 | 0.01±0.01 |
| GA | 4.27±0.97 | 2.01±1.63 | 2.42±0.82 | 1.18±0.35 | 14.41±19.65 | 16.53±11.09 | 0.36±0.66 | 0.01±0 | |
| GG | 5.79±3.05 | 2.28±1.84 | 3.61±2.33 | 1.34±0.51 | 5.32±2.27 | 13.78±13.38 | 0.48±0.63 | 0.01±0 | |
| p | 0.036 * | 0.224 | 0.043 * | 0.895 | 0.432 | 0.585 | 0.527 | 0.271 | |
| rs231362 | GG | 4.56±1.35 | 2.6±2.38 | 2.62±1.04 | 1.19±0.58 | 43.26±140.4 | 19.28±19.35 | 0.58±1.39 | 0.01±0.01 |
| AG | 4.46±1.24 | 2.25±1.99 | 2.65±1.08 | 2.64±14.68 | 17.99±28.82 | 18.03±17.19 | 0.35±0.6 | 0.01±0 | |
| AA | 4.54±1.26 | 2.14±1.31 | 2.52±0.94 | 1.2±0.32 | 35.99±59.34 | 10.83±3.62 | 1.84±2.79 | 0.02±0.03 | |
| p | 0.813 | 0.438 | 0.53 | 0.249 | 0.37 | 0.558 | 0.015 * | 0.001 * | |
| rs231356 | TT | 4.57±1.37 | 2.74±2.55 | 2.61±1.01 | 1.2±0.65 | 47.4±151.48 | 19.59±20.18 | 0.52±1.13 | 0.01±0.01 |
| AT | 4.48±1.28 | 2.2±1.81 | 2.65±1.14 | 2.3±12.98 | 19.02±29.39 | 18.93±16.7 | 0.54±1.41 | 0.01±0.01 | |
| AA | 4.38±0.93 | 1.75±0.87 | 2.5±0.7 | 1.25±0.3 | 20.87±37.59 | 9.49±5.92 | 0.82±1.82 | 0.01±0.02 | |
| p | 0.685 | 0.052 | 0.802 | 0.406 | 0.206 | 0.116 | 0.664 | 0.472 | |
| rs8181588 | TT | 4.45±1.26 | 2.32±2.16 | 2.55±0.9 | 1.24±0.59 | 23.53±53.5 | 18.02±20.72 | 0.51±1.41 | 0.01±0.01 |
| CT | 4.55±1.3 | 2.41±1.89 | 2.67±1.14 | 1.16±0.44 | 39.25±96.25 | 18.49±15.72 | 0.6±1.23 | 0.01±0 | |
| CC | 4.83±1.61 | 3.76±3.64 | 2.68±1.16 | 4.81±23.44 | 89.42±305.03 | 23.76±20.58 | 0.44±0.67 | 0.01±0.01 | |
| p | 0.226 | 0.006 * | 0.547 | 0.015 * | 0.040 * | 0.317 | 0.746 | 0.871 | |
| rs163177 | TT | 4.53±1.32 | 2.91±2.59 | 2.54±0.81 | 1.27±0.77 | 39.49±70.33 | 23.77±24.17 | 0.75±1.36 | 0.01±0 |
| CT | 4.54±1.36 | 2.6±2.35 | 2.65±1.18 | 1.84±10.21 | 45.72±159.06 | 16.65±12.19 | 0.5±1.34 | 0.01±0.01 | |
| CC | 4.55±1.21 | 1.96±1.65 | 2.61±0.85 | 1.25±0.36 | 14.82±16.42 | 19.32±23.74 | 0.47±1.06 | 0.01±0.01 | |
| p | 0.993 | 0.038 * | 0.692 | 0.756 | 0.261 | 0.039 * | 0.384 | 0.411 | |
| rs163184 | TT | 4.51±1.38 | 2.88±2.7 | 2.47±0.85 | 2.82±15.42 | 41.16±68.58 | 21.56±22.5 | 0.77±1.51 | 0.01±0 |
| GT | 4.52±1.34 | 2.57±2.28 | 2.68±1.19 | 1.15±0.58 | 45.57±161.67 | 16.81±12.79 | 0.47±1.25 | 0.01±0.01 | |
| GG | 4.59±1.22 | 1.99±1.65 | 2.63±0.85 | 1.26±0.36 | 13.63±14.09 | 20.25±23.98 | 0.47±1.06 | 0.01±0.01 | |
| p | 0.897 | 0.051 | 0.264 | 0.188 | 0.233 | 0.165 | 0.243 | 0.185 | |
| rs2283228 | CC | 4.67±1.29 | 3.17±2.9 | 2.61±0.69 | 5.79±26.86 | 27.66±35.16 | 25.41±20.86 | 0.54±0.73 | 0.01±0.01 |
| CA | 4.53±1.4 | 2.59±2.39 | 2.62±1.2 | 1.19±0.63 | 54.34±179.24 | 17.51±15.08 | 0.59±1.28 | 0.01±0 | |
| AA | 4.51±1.24 | 2.32±2.04 | 2.6±0.92 | 1.23±0.56 | 24.71±54.92 | 18.82±20.72 | 0.51±1.35 | 0.01±0.01 | |
| p | 0.811 | 0.198 | 0.987 | 0.005 * | 0.169 | 0.169 | 0.89 | 0.784 | |
| rs2237895 | CC | 4.51±1.36 | 2.23±2.09 | 2.53±0.84 | 1.23±0.41 | 16.24±17.57 | 21.84±28.94 | 0.51±0.96 | 0.01±0.01 |
| CA | 4.63±1.32 | 2.58±2.41 | 2.75±1.21 | 1.99±11.12 | 46.35±171.08 | 18.23±14.55 | 0.47±1.38 | 0.01±0.01 | |
| AA | 4.4±1.28 | 2.51±2.15 | 2.47±0.83 | 1.21±0.61 | 34.99±64.33 | 18.56±18.2 | 0.65±1.26 | 0.01±0.01 | |
| p | 0.296 | 0.662 | 0.038 * | 0.6 | 0.405 | 0.539 | 0.542 | 0.848 |
Notes: Data are presented as means SD or percentages; *p value < 0.05 indicates statistical significance (p < 0.05) are in bold.
Abbreviations: HDL-C, high-density lipoprotein cholesterol; LDL-C, high-density lipoprotein cholesterol; TC, total cholesterol; ALBP, Adipocyte Lipid-binding Protein; INS, insulin; UCRP (ubiquitin cross-reacting protein); KCNQ1, Potassium Voltage-Gated Channel Subfamily Q Member 1; T2DM, type 2 diabetes mellitus.