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. 2021 Dec 31;14:1731–1751. doi: 10.2147/PGPM.S340813

Table 8.

SNP–SNP Interaction Models of the KCNQ1 Gene the Predisposition of T2DM

Model Testing Bal. Acc. CVC OR (95% CI) p
rs2283228 0.511 5/10 1.36 (1.06–1.75) 0.017
rs2237895, rs163177 0.509 8/10 1.63 (1.25–2.13) <0.001
rs2237895, rs2283228, rs163177 0.524 5/10 1.92 (1.49–2.48) <0.001
rs2237895, rs2283228, rs163177, rs8181588 0.546 9/10 2.62 (2.00–3.44) <0.001
rs2237895, rs2283228, rs231356, rs163177, rs8181588 0.554 10/10 3.34 (2.54–4.40) <0.001
rs2237895, rs2283228, rs231356, rs117601636, rs163177, rs8181588 0.568 10/10 4.10 (3.12–5.39) <0.001
rs2237895, rs2283228, rs231356, rs231362, rs117601636, rs163177, rs8181588 0.555 10/10 4.75 (3.59–6.28) <0.001
rs2237895, rs2283228, rs231356, rs231362, rs117601636, rs163177, rs163184, rs8181588 0.542 10/10 5.15 (3.85–6.90) <0.001

Notes: p values were calculated using χ2 tests. Bold indicated that p < 0.05 meant the data was statistically significant.

Abbreviations: MDR, multifactor dimensionality reduction; Bal. Acc., balanced accuracy; CVC, cross–validation consistency; KCNQ1, Potassium Voltage-Gated Channel Subfamily Q Member 1; T2DM, type 2 diabetes mellitus.