Table 4.
Multivariate regression analysis for mortality in the entire cohort.
| Variable | aOR (95% CI), p |
|---|---|
| Corticosteroid treatment | 0.26 (0.19–0.36), < .001 |
| Male sex | 1.57 (1.14–2.14), .005 |
| Age | 1.07 (1.06–1.08), < .001 |
| Diabetes mellitus | 1.31 (0.96–1.82), .084 |
| Hypertension | 0.98 (0.71–1.37), .924 |
| Cardiovascular disease | 0.84 (0.47–1.51), .567 |
| Chronic kidney disease | 1.57 (0.74–3.33), .242 |
| Baseline lymphocyte count < 800 cells/µL | 1.54 (1.13–2.10), .006 |
| Baseline C-reactive protein > 10 mg/dL | 3.28 (2.20–4.90), <.001 |
| Baseline D-dimer > 1000 ng/mL | 1.63 (1.22–2.19), .001 |
| Baseline oxygen saturation ≤ 90% | 1.58 (0.66–3.75), .303 |
| Use of mechanical ventilation | 5.66 (3.8–8.43), <.001 |
| Tocilizumab | 1.08 (0.62–1.90), .787 |
| Participation in a clinical trial | 0.30 (0.19–0.48), <.001 |
| Hospital-acquired infection | 0.68 (0.43–1.08), .099 |
| 1432 observations, AUC 0.8507, Pseudo-R2 0.2847 | |
Elevated lactate dehydrogenase, troponin I, ferritin, and PaO2/FiO2 ratio were not included in the model to avoid excessive laboratory abnormalities that are known to be present in patients with severe COVID-19.
ICU admission was not included in the model because in our centre, ICU admission is highly concordant with use of mechanical ventilation.
CI, confidence interval; aOR, adjusted odds ratio.