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Efficacy and tolerability of Celastrol and Cel-CSO in a mouse model bearing human pancreatic cancer with oral administration every two days. (A) BxPC-3 solid tumor volume over time; (B) the tumor inhibition index at the end of experiment; (C) mouse body weight over time. Tumor inhibition rate (TIR) = [(tumor volume of control group – tumor volume of drug group)/tumor volume of control group] × 100%. **p < .01, ****p < .0001, vs. Control group; ##p < .01, vs. Celastrol group (1 mg/kg).
