Figure 3.
2–36 neutralizes SARS-CoV-2 variants and SARS-CoV-like coronaviruses. (A) 2–36 neutralization IC50 (µg/mL) against SARS-CoV-2 variants. (B) Phylogenetic tree of SARS-CoV-2- and SARS-CoV-related lineages and other coronaviruses constructed via MEGA7 and maximum likelihood analysis of spike amino acid sequences extracted from the NCBI and GISAID database. Representative viruses selected for further testing are denoted in colour same as in (C). (C) Heatmap showing the neutralization IC50 values of the indicated antibodies against SARS-CoV-2, SARS-CoV and their related sarbecoviruses.