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. 2021 Dec 21;12:703883. doi: 10.3389/fgene.2021.703883

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Copyright © 2021 Zeinalzadeh, Valerievich Yumashev, Rahman, Marofi, Shomali, Kafil, Solali, Sajjadi-Dokht, Vakili-Samiani, Jarahian and Hagh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The structure of signal transducer and activator of transcription (STAT) family. A full-length stat consists of N-Terminal domain (required for STAT oligomerization and stabilization on DNA), Coiled-Coiled domain (needed as a nuclear localization signal for stimulation), DNA binding domain (binds DNA elements), linker domain, src homology 2 domain (SH2: mediated homo or heterodimer formation, bind transcriptional activation domain of adjacent STAT monomer), and C-terminal transcriptional activation domain (TAD: Y and S within the C-terminal are the phosphorylation sites).