Table 2.
EGF and endochondral ossification database.
| Authors | Year | Type of study | Results |
|---|---|---|---|
| Chenevix-Trench, G., et al. | 1992 | In vivo, human | Cleft palate associated with polymorphism in TGFA gene |
| Threadgill, D.W., et al. | 1995 | In vivo, mouse | EGFR null mice have prenatal and postnatal defects and growth retardation based on the genetic background |
| Miettinen, P.J., et al. | 1995 | In vivo, mouse | EGFR null mice have epithelial alterations and dysfunctions in several tissues and growth retardation |
| Monsonego E., et al. | 1995 | In vitro, avian epiphyseal chondrocytes | EGF and GH increase cell proliferation |
| Huang, L., et al. | 1996 | In vitro, rat micromass culture | TGF-α prevents chondrocyte differentiation |
| Bonassar, L.J., et al. | 1997 | In vitro, rabbit | EGF interacts with IGF-1 in skeletal growth |
| Dealy, C.N., et al. | 1998 | In vitro, embryonic chick limb | Exogenous TGF-a and EGF inhibit chondrogenesis and myogenesis of limb mesenchyme |
| Miettinen, P.J., et al. | 1999 | In vivo, mouse | EGFR null mice have impaired craniofacial development |
| Yoon, Y.M., et al. | 2000 | In vitro, micromass culture of chick limb bud | EGF negatively regulates chondrogenesis by modulating PKC, Erk-1, p38 MAPK |
| Chan, S.Y., et al. | 2000 | In vivo, mouse | Overexpression of human EGF impairs endochondral development |
| Sibilia, M., et al. | 2003–2016 | In vivo, mouse | Mice humanised for EGFS display growth retardation |
| Wang, K., et al. | 2004 | In vivo, mouse | EGFR-deficient mice have delayed primary endochondral ossification |
| Schneider, M.R., et al. | 2005 | In vivo, mouse | BTC overexpressing mice display growth retardation and reduced bone dimensions |
| Fisher, M.C., et al. | 2007 | In vivo, mouse | Inhibition of EGF signalling causes delayed endochondral ossification and impaired chondrocyte and osteoblast proliferation |
| Schneider, M.R., et al. | 2009 | In vivo, mouse | BTC overexpressing mice display increased BMD and bone cortical mass |
| Genetos, D.C., et al. | 2010 | In vitro, human MSCs | BTC promotes proliferation but it inhibits differentiation upon HIF-1α regulation |
| Zhang, X., et al. | 2011 | In vivo, mouse | EGFR conditional knockout in pre-osteoblasts causes reduced trabecular and cortical volume |
| Usmani S.E., et al. | 2012 | In vivo, mouse | TGF-α knockout model shows impaired endochondral development ut to 10 weeks postnatally |
| Hall, K.C., et al., | 2013 | In vivo, in vitro, mouse | ADAM17 conditional knockout in chondrocytes displays a significant expansion of hypertrophic chondrocytes |
| Saito K., et al. | 2013 | In vivo, mouse | TACE conditional knockout in chondrocytes delays hypertrophy through EGFR signalling |
| Pruvot B., et al. | 2014 | In vivo, zebrafish | Inhibition of EGF signalling impairs Meckel’s cartilage development |
| Chim, S.M., et al. | 2015 | In vitro, in vivo, mouse | EGFL7 regulates angiogenesis in bone microenvironment |
| Lin, Y.C., et al. | 2015 | In vitro, in vivo, mouse | Scube2 knockout impairs Ihh-dependent endochondral ossification |
| Wolf, C.J., et al. | 2018 | In vitro, organoids from human umbilical MSCs | EGF promotes proliferation during palate development |
| Li P., et al. | 2019 | In vitro, in vivo, mouse BMSCs, mouse | HB_EGF overexpression in osteoprogenitor cells causes chondrodysplasia, chondromas and sorter long bones |
| Fang, R., et al. | 2020 | In vivo, mouse | iRhoms 1 and 2 conditional knockout in chondrocytes impairs endochondral ossification |
| Lin, Y.C., et al. | 2021 | In vitro, In vivo, mouse, human | Scube3 loss of function causes growth disorders by impairing BMP signalling |