Table 1.
Selected proteins identified in the LAT by nano-LC-MS/MS
| Protein nameAdipokines | Functionsa | Accession codeb |
|---|---|---|
| Visfatin | Cell proliferation | P43490 |
| Adiponectin | Hormone, cell growth, differentiation and angiogenesis | Q15848 |
| Retinoic acid receptor responder protein 2 | Regulates adipogenesis and adipocyte differentiation | Q99969 |
| Complement factor D | P00746 | |
| Retinol-binding protein 4 | P02753 | |
| SPARC | Cell growth | P09486 |
| Angiogenic proteins | ||
| TNF α- induced protein 2 | Angiogenesis and differentiation | Q03169 |
| Angiopoietin-1 (Ang-1) | Angiogenesis and cell survival | Q15389 |
| Angiopoietin-2 (Ang-2) | Angiogenesis and differentiation | O15123 |
| Angio-associated migratory cell protein | Angiogenesis and differentiation | Q13685 |
| Angiopoietin-1 receptor | Angiogenesis and cell survival | Q15389 |
| Angiopoietin-related protein 2 | Angiogenesis | Q9UKU9 |
| Angiopoietin-related protein 4 | Angiogenesis and differentiation | Q9BY76 |
| Pericyte markers | ||
| Desmin | Muscle protein | P17661 |
| Platelet-derived growth factor receptor β (PDGFR-β) | Cell proliferation and differentiation | P09619 |
| Chondroitin sulphate proteoglycan 4 (NG2) | Angiogensis and cell proliferation | Q6UVK1 |
| Aminopeptidase N (APN, CD13) | Angiogenesis and cell differentiation | P15144 |
| Vimentin | P08670 | |
| Cell surface glycoprotein MUC18 (MCAM and CD146) | Angiogenesis | P43121 |
| Endosialin (CD248) | Cell proliferation | Q9HCU0 |
| Neurogenic locus notch homolog protein 3 (NOTCH3) | Angiogenesis and cell differentiation | Q9UM47 |
| Growth factors and associated proteins | ||
| Transforming growth factor β1 (TGF-β1) | Cell survival and proliferation | P01137 |
| Fibroblast growth factor 1 (FGF-1) | Cell survival, angiogenesis and differentiation | P05230 |
| Fibroblast growth factor 2 (FGF-2) | Cell survival, angiogenesis and differentiation | P09038 |
| Epidermal growth factor-like protein 6 | Differentiation | Q8IUX8 |
| Epidermal growth factor-like protein 7 | Angiogenesis | Q9UHF1 |
| Hepatoma-derived growth factor (HDGF) | Cell proliferation | P51858 |
| Hepatoma-derived growth factor-related protein 2 (HRP-2) | Cell growth | Q7Z4V5 |
| Hepatoma-derived growth factor-related protein 3 (HRP-3) | Cell proliferation | Q9Y3E1 |
| Myeloid-derived growth factor (MYDGF and IL-25) | Angiogenesis and cell proliferation | Q969H8 |
| Stromal/stem cell-derived factor 1 (SDF-1) | Growth factor and chemokine activity | P48061 |
| Growth factor receptors | ||
| Fibroblast growth factor receptor 1 (FGFR-1) | Angiogenesis and differentiation | P11362 |
| Vascular endothelial growth factor receptor 1 (VEGFR-1) | Angiogenesis, cell proliferation and survival | P17948 |
| Vascular endothelial growth factor receptor 3 (VEGFR-3) | Lymphangiogenesis and angiogenesis | P35916 |
| Insulin receptor | Cell proliferation | P06213 |
| Insulin-like growth factor 1 receptor (IGF1R) | Cell proliferation | P08069 |
| Epidermal growth factor receptor | Cell growth | P00533 |
| Platelet-derived growth factor receptor β (PDGFR-β) | Cell proliferation and differentiation | P09619 |
| Platelet-derived growth factor receptor α (PDGFR-α) | Cell proliferation and differentiation | P16234 |
| TNF receptor superfamily member 1A | Angiogenesis and cell proliferation | P19438 |
| TNF receptor superfamily member 5 | Cell proliferation | P25942 |
| GF-binding proteins | ||
| Growth factor receptor-bound protein 2 | Cell proliferation and differentiation | P62993 |
| Insulin-like growth factor 2 mRNA-binding protein 2 (IGFBP-2) | Q9Y6M1 | |
| Insulin-like growth factor-binding protein 3 (IGFBP-3) | Cell growth, proliferation and differentation | P17936 |
| Insulin-like growth factor-binding protein 5 (IGFBP-5) | Cell growth, proliferation and differentiation | P24593 |
| Insulin-like growth factor-binding protein 6 (IGFBP-6) | Cell growth | P24592 |
| Insulin-like growth factor-binding protein 7 (IGFBP-7) | Cell growth | Q16270 |
| Acidic fibroblast growth factor intracellular-binding protein (FGF-1 intracellular-binding protein) | O43427 | |
| Latent-transforming growth factor beta-binding protein 1 (LTBP-1) | Structural role in ECM | Q14766 |
| Latent-transforming growth factor beta-binding protein 2 (LTBP-2) | Structural role in ECM | Q14767 |
| Latent-transforming growth factor beta-binding protein 3 (LTBP-3) | Structural role in ECM | Q9NS15 |
| Latent-transforming growth factor beta-binding protein 4 (LTBP-4) | Cell growth anddifferentiation | Q8N2S1 |
| TNF receptor-associated factor 2 | Q12933 | |
| TNF receptor-associated factor 6 | Osteoclast differentiation and smooth muscle proliferation | Q9Y4K3 |
| TNF receptor type 1-associated DEATH domain protein | Q15628 | |
| Extracellular matrix (ECM) proteins | ||
| Collagen type IV | Basement membrane associated | P02462 and P08572 |
| Laminin α 2, 3, 4 and 5 | Basement membrane associated | P24043, Q16787, Q16363 and O15230 |
| Laminin β 1, 2 and 3 | Basement membrane associated | P07942, P55268 and Q13751 |
| Lamnin γ 1 | Basement membrane associated | P11047 |
| Agrin | Basement membrane associated | O00468 |
| Perlecane (Basement membrane-specific heparan sulphate proteoglycan core protein) | Basement membrane associated and angiogenesis | P98160 |
| Fibronectin | Basement membrane associated | P02751 |
| Nidogen-1 | Basement membrane associated | P14543 |
| Nidogen-2 | Basement membrane associated | Q14112 |
aAccording to the UniProtKB database. b Protein accession code from Swiss-Prot database