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. 2021 Jan 18;17(12):3897–3907. doi: 10.1080/15548627.2021.1872240

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Schematic structural models of mutually exclusive complex I (left) and complex II (right). PIK3C3/Vps34, PIK3R4/Vps15, and BECN1/Vps30 are found in both complexes, whereas ATG14/Atg14 is complex I-specific, and UVRAG/Vps38 is complex II-specific. Complex I associates with membranes via the aromatic finger 1 in the BECN1 BARA domain and the BATS domain in ATG14 (which does not exist in Atg14). Complex II associates with membranes via two aromatic finger motifs (aromatic fingers 1 and 2) and the hydrophobic loop, all of which are in the BECN1 BARA domain. C2: C2 domain; CC: Coiled-coil; BARA: BARA domain; BATS: BATS domain; NTD: N terminal domain; CTD: C terminal domain; CXXCs: CXXC motifs; WD40: WD40 domain