Figure 3.

Binding stoichiometry between complex I and NRBF2/Atg38. In mammals, the stoichiometry between complex I and NRBF2 is 1:2 (one copy of complex I and one homodimer of NRBF2, left) when NRBF2 is more abundant than complex I, whereas it can be 2:2 (two copies of complex I and one homodimer of NRBF2, right) when complex I is more abundant than NRBF2. In yeast the stoichiometry is always 1:2 regardless of the comparative abundance between complex I and Atg38. It must be noted that the complex I subunit (S) binding to the MIT domain is still speculative