Figure 7.

Model for the distinct regulation of autophagy by EDTP and Mtmr6. Under nutrient-rich condition, EDTP inhibits basal autophagy by antagonizing PtdIns3P production and suppressing autophagosome maturation. In contrast, Mtmr6 promotes autophagy in well-fed animals, affecting the process at a later stage. Under conditions of cellular stress, the autophagy flux is not altered by EDTP, but is markedly lowered by Mtmr6. Mtmr6 prevents the harmful hyperactivation of autophagy during stress by antagonizing PtdIns3K