TABLE 1.

Levels of radioactivity in female wild-type and Oct1^−/− mice at 20 min after i.v. injection of [¹⁴C]TEA (0.2 mg/kg)^a

Tissue	Mean 14C concn (ng-eq g−1 or ml−1) ± SD (n = 4)		Ratio, Oct1−/−/wt	Mean excretion (%) ± SD (n = 4)c		Ratio, Oct1−/−/wt
	wt	Oct1−/−		wt	Oct1−/−
Plasma	77 ± 60	41 ± 35	0.53
Brain	2.3 ± 1.5	2.9 ± 2.8	1.24
Spleen	42 ± 6	42 ± 12	1.02
Kidney	418 ± 63	584 ± 483	1.40
Liver	892 ± 283 (18.1 ± 3.3b)	100 ± 33** (2.8 ± 0.7**)	0.11 (0.15)
Small intestine				2.41 ± 1.00	0.21 ± 0.09**	0.09
Cecum				0.30 ± 0.20	0.05 ± 0.04*	0.16
Colon				0.10 ± 0.06	0.01 ± 0.01*	0.13
Urine				45.7 ± 3.4	70.3 ± 12.4**	1.54

^awt, wild type; *, P < 0.05; **, P < 0.01. 

^bMean percentage of administered dose ± SD (n = 4). 

^cTotal TEA found in the contents of small intestine, cecum, and colon. Urine was collected from the bladder.